The Digital Research Infrastructure for Integrative Molecular Biology (DRIIMB) inaugural Integrative Structural Biology Conference (2026) will bring together researchers from across the field to explore current advances and future directions. The programme will feature sessions on community and resource building through data and software, the successes and challenges of integrative biology, and the role of data-driven and physics-based models in advancing our understanding of biological systems. The conference will also include poster sessions with flash presentations and panel discussions on the future scope of DRIIMB and integrative biology.